' 
![]()
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.8
USERS' SCORE
Good
Based on 3 Reviews
8.7
Supplement Facts
Serving Size: 1 Softgel
Serving Per Container: 30
Amount Per Serving
%DV
Calories
5
Total Fat
0.5 g
<1%¹
Total Omega-3 Fatty Acids
365 mg
DHA (Docosahexaenoic Acid)
350 mg
+
EPA (Eicosapentaenoic Acid)
15 mg
+
Top Medical Research Studies
9
DHA lowers cholesterol; boosts metabolism
F-Fluorodeoxyglucose positron emission tomography/computed tomography imaging reveals the protective effect of docosahexaenoic acid on glucose metabolism by reducing brain 27-hydroxycholesterol.
Directly addresses cholesterol effects
We aimed to investigate how docosahexaenoic acid (DHA) impacts cholesterol levels and brain glucose metabolism. In our study, we focused on aged SAMP8 mice, dividing them into two groups: a control group and one receiving DHA supplementation.
Our results revealed encouraging changes; the group that received DHA showed a decrease in total cholesterol and low-density lipoprotein cholesterol, while high-density lipoprotein cholesterol levels increased. More importantly, we observed improvements in glucose metabolism in various brain regions, including the cortex and hippocampus.
These findings suggest that DHA may help lower harmful cholesterol levels and enhance brain function by regulating specific cholesterol compounds like 27-hydroxycholesterol, which are linked to glucose metabolism. Overall, our study highlights DHA's potential in supporting heart and brain health through cholesterol management.
Our results revealed encouraging changes; the group that received DHA showed a decrease in total cholesterol and low-density lipoprotein cholesterol, while high-density lipoprotein cholesterol levels increased. More importantly, we observed improvements in glucose metabolism in various brain regions, including the cortex and hippocampus.
These findings suggest that DHA may help lower harmful cholesterol levels and enhance brain function by regulating specific cholesterol compounds like 27-hydroxycholesterol, which are linked to glucose metabolism. Overall, our study highlights DHA's potential in supporting heart and brain health through cholesterol management.
Read More
9
Eicosapentaenoic acid benefits cholesterol
Omega-3 eicosapentaenoic polar-lipid rich extract from microalgae decreases plasma triglycerides and cholesterol in a real-world normolipidemic supplement consumer population.
Direct focus on EPA's efficacy
We explored the effects of eicosapentaenoic acid (EPA), a specific type of omega-3 fatty acid, on cholesterol levels in a recent study involving real-world supplement consumers. Participants took AlmegaPL capsules, which contain high amounts of EPA and are free of the other omega-3 fatty acid, DHA. This setup allowed us to gain insights from those who are already incorporating EPA into their diets.
Throughout the study, we monitored key health markers such as triglycerides, total cholesterol, and various types of cholesterol at different stages of supplementation. We observed that after six months of taking this supplement, participants showed a significant reduction in remnant cholesterol and maintained healthy triglyceride levels. Notably, this decrease in cholesterol did not come at the expense of raising low-density lipoprotein (LDL) levels, which is often a concern with other treatments.
These encouraging results reveal that EPA can be a beneficial addition for individuals looking to manage their cholesterol levels effectively. Importantly, our findings highlight AlmegaPL's unique position as a natural, over-the-counter option for those seeking to improve their lipid profiles.
Throughout the study, we monitored key health markers such as triglycerides, total cholesterol, and various types of cholesterol at different stages of supplementation. We observed that after six months of taking this supplement, participants showed a significant reduction in remnant cholesterol and maintained healthy triglyceride levels. Notably, this decrease in cholesterol did not come at the expense of raising low-density lipoprotein (LDL) levels, which is often a concern with other treatments.
These encouraging results reveal that EPA can be a beneficial addition for individuals looking to manage their cholesterol levels effectively. Importantly, our findings highlight AlmegaPL's unique position as a natural, over-the-counter option for those seeking to improve their lipid profiles.
Read More
9
Eicosapentaenoic acid reduces cholesterol inflammation
EPA and DHA inhibit LDL-induced upregulation of human adipose tissue NLRP3 inflammasome/IL-1β pathway and its association with diabetes risk factors.
Relevant support for cholesterol management
We explored how eicosapentaenoic acid (EPA) affects cholesterol levels and the risk of type 2 diabetes (T2D). Our study focused on individuals with high levels of atherogenic lipoproteins, specifically apoB, which are known to predict higher diabetes risk. Over a twelve-week period, participants received daily doses of EPA and docosahexaenoic acid (DHA) to see how these omega-3 fatty acids influenced the secretion of interleukin-1 beta (IL-1β) from human white adipose tissue (WAT).
Remarkably, our results showed that EPA and DHA treatment effectively normalized the IL-1β secretion levels in participants who initially had high apoB. After the intervention, LDL cholesterol no longer triggered IL-1β secretion, and the omega-3 supplementation also improved overall β-cell function and fat metabolism. This means that not only did EPA and DHA reduce inflammation linked to high cholesterol, but they also appeared to enhance metabolic health.
Additionally, we found that the supplementation reduced the association between WAT inflammasome activity and various cardiometabolic risk factors, such as increased body fat. In laboratory tests, EPA and DHA inhibited WAT IL-1β secretion in a dose-dependent manner. These findings suggest that incorporating EPA and DHA into our diets may help prevent diabetes and its related health issues in individuals with high apoB levels.
Remarkably, our results showed that EPA and DHA treatment effectively normalized the IL-1β secretion levels in participants who initially had high apoB. After the intervention, LDL cholesterol no longer triggered IL-1β secretion, and the omega-3 supplementation also improved overall β-cell function and fat metabolism. This means that not only did EPA and DHA reduce inflammation linked to high cholesterol, but they also appeared to enhance metabolic health.
Additionally, we found that the supplementation reduced the association between WAT inflammasome activity and various cardiometabolic risk factors, such as increased body fat. In laboratory tests, EPA and DHA inhibited WAT IL-1β secretion in a dose-dependent manner. These findings suggest that incorporating EPA and DHA into our diets may help prevent diabetes and its related health issues in individuals with high apoB levels.
Read More
Most Useful Reviews
9.5
Cholesterol reduction
Omega-3 acids cleanse blood vessel walls from excess high cholesterol, helping prevent cholesterol plaques. They improve blood viscosity and normalise blood pressure while increasing the level of "good" cholesterol, HDL, and strengthen blood vessel walls, enhancing their elasticity.
Read More
9.5
Effective treatment
The correct ratio of DHA to EPA (2:1) and high purification quality significantly impact high cholesterol levels.
Read More
9.5
Lower cholesterol
Omega-3 reduces harmful cholesterol levels in the blood. They serve as a building block for neural membranes and are involved in oxygen transportation.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.8
9
Krill oil supports cholesterol management
Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice.
Moderate relevance for DHA impact
We explored how Antarctic krill oil, particularly its key components like docosahexaenoic acid (DHA), can combat high cholesterol and obesity-related issues. Our study focused on its effects in a controlled environment using obese mice that were fed a high-fat diet.
We observed that when these mice were supplemented with krill oil, there were notable reductions in cholesterol levels and fat accumulation. It seemed to positively influence various metabolic pathways, such as those associated with cholesterol metabolism.
Specifically, DHA, along with other nutrients found in krill oil, appears to aid in lowering oxidative stress and improving cholesterol metabolism. While the benefits of DHA alone weren't isolated in this study, the overall findings suggest that krill oil may work effectively in reducing the risks tied to obesity and high cholesterol.
Overall, this research indicates that incorporating krill oil into our diets could be a promising strategy for managing cholesterol levels and supporting heart health.
We observed that when these mice were supplemented with krill oil, there were notable reductions in cholesterol levels and fat accumulation. It seemed to positively influence various metabolic pathways, such as those associated with cholesterol metabolism.
Specifically, DHA, along with other nutrients found in krill oil, appears to aid in lowering oxidative stress and improving cholesterol metabolism. While the benefits of DHA alone weren't isolated in this study, the overall findings suggest that krill oil may work effectively in reducing the risks tied to obesity and high cholesterol.
Overall, this research indicates that incorporating krill oil into our diets could be a promising strategy for managing cholesterol levels and supporting heart health.
Read More
9
DHA supplementation for cholesterol management
EPA and DHA inhibit LDL-induced upregulation of human adipose tissue NLRP3 inflammasome/IL-1β pathway and its association with diabetes risk factors.
Study highlights DHA's impact
We explored how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, influences levels of bad cholesterol and related diabetes risk. In a comprehensive study, participants were given a daily supplement of both EPA and DHA for twelve weeks. This supplementation aimed to see if it could counteract the negative effects of low-density lipoproteins (LDL) on human adipose tissue.
The results were quite revealing. Before the intervention, we noticed a significant difference in interleukin-1 beta (IL-1β) secretion, a pro-inflammatory substance linked to higher cholesterol levels, between individuals with high and low levels of atherogenic lipoproteins (apoB). After the supplementation with EPA and DHA, this inflammatory response was significantly reduced in those with high apoB. Not only did the fatty acids inhibit IL-1β secretion triggered by LDL, but they also improved fat metabolism and insulin response.
Furthermore, we observed that the omega-3 supplementation addressed various cardiometabolic risk factors, including those related to adiposity. The study indicated that DHA, alongside EPA, plays a role in managing inflammatory responses that contribute to high cholesterol levels and diabetes risk.
In conclusion, incorporating DHA as part of omega-3 supplementation could be a valuable strategy for those with elevated cholesterol levels, especially in preventing type 2 diabetes and its associated health issues.
The results were quite revealing. Before the intervention, we noticed a significant difference in interleukin-1 beta (IL-1β) secretion, a pro-inflammatory substance linked to higher cholesterol levels, between individuals with high and low levels of atherogenic lipoproteins (apoB). After the supplementation with EPA and DHA, this inflammatory response was significantly reduced in those with high apoB. Not only did the fatty acids inhibit IL-1β secretion triggered by LDL, but they also improved fat metabolism and insulin response.
Furthermore, we observed that the omega-3 supplementation addressed various cardiometabolic risk factors, including those related to adiposity. The study indicated that DHA, alongside EPA, plays a role in managing inflammatory responses that contribute to high cholesterol levels and diabetes risk.
In conclusion, incorporating DHA as part of omega-3 supplementation could be a valuable strategy for those with elevated cholesterol levels, especially in preventing type 2 diabetes and its associated health issues.
Read More
9
DHA lowers cholesterol; boosts metabolism
F-Fluorodeoxyglucose positron emission tomography/computed tomography imaging reveals the protective effect of docosahexaenoic acid on glucose metabolism by reducing brain 27-hydroxycholesterol.
Directly addresses cholesterol effects
We aimed to investigate how docosahexaenoic acid (DHA) impacts cholesterol levels and brain glucose metabolism. In our study, we focused on aged SAMP8 mice, dividing them into two groups: a control group and one receiving DHA supplementation.
Our results revealed encouraging changes; the group that received DHA showed a decrease in total cholesterol and low-density lipoprotein cholesterol, while high-density lipoprotein cholesterol levels increased. More importantly, we observed improvements in glucose metabolism in various brain regions, including the cortex and hippocampus.
These findings suggest that DHA may help lower harmful cholesterol levels and enhance brain function by regulating specific cholesterol compounds like 27-hydroxycholesterol, which are linked to glucose metabolism. Overall, our study highlights DHA's potential in supporting heart and brain health through cholesterol management.
Our results revealed encouraging changes; the group that received DHA showed a decrease in total cholesterol and low-density lipoprotein cholesterol, while high-density lipoprotein cholesterol levels increased. More importantly, we observed improvements in glucose metabolism in various brain regions, including the cortex and hippocampus.
These findings suggest that DHA may help lower harmful cholesterol levels and enhance brain function by regulating specific cholesterol compounds like 27-hydroxycholesterol, which are linked to glucose metabolism. Overall, our study highlights DHA's potential in supporting heart and brain health through cholesterol management.
Read More
9
Eicosapentaenoic acid aids cholesterol
Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice.
Study shows EPA's combined effects
We explored the effects of eicosapentaenoic acid (EPA) from Antarctic krill oil (ESKO) on cholesterol levels and obesity-related conditions. Through a carefully designed study involving mice on a high-fat diet, we wanted to see if ESKO could improve cholesterol metabolism and reduce fat accumulation.
We found that diets high in fat significantly increased oxidative stress and indicators associated with obesity. However, supplementation with ESKO appeared to counteract these negative effects, helping to reduce fat buildup and improve cholesterol levels.
Specifically, ESKO improved important metabolic pathways and reduced the activity of certain proteins that typically promote high cholesterol. This suggests that eicosapentaenoic acid from krill oil could play a crucial role in tackling high cholesterol and obesity-related disorders.
We found that diets high in fat significantly increased oxidative stress and indicators associated with obesity. However, supplementation with ESKO appeared to counteract these negative effects, helping to reduce fat buildup and improve cholesterol levels.
Specifically, ESKO improved important metabolic pathways and reduced the activity of certain proteins that typically promote high cholesterol. This suggests that eicosapentaenoic acid from krill oil could play a crucial role in tackling high cholesterol and obesity-related disorders.
Read More
9
Eicosapentaenoic acid reduces cholesterol inflammation
EPA and DHA inhibit LDL-induced upregulation of human adipose tissue NLRP3 inflammasome/IL-1β pathway and its association with diabetes risk factors.
Relevant support for cholesterol management
We explored how eicosapentaenoic acid (EPA) affects cholesterol levels and the risk of type 2 diabetes (T2D). Our study focused on individuals with high levels of atherogenic lipoproteins, specifically apoB, which are known to predict higher diabetes risk. Over a twelve-week period, participants received daily doses of EPA and docosahexaenoic acid (DHA) to see how these omega-3 fatty acids influenced the secretion of interleukin-1 beta (IL-1β) from human white adipose tissue (WAT).
Remarkably, our results showed that EPA and DHA treatment effectively normalized the IL-1β secretion levels in participants who initially had high apoB. After the intervention, LDL cholesterol no longer triggered IL-1β secretion, and the omega-3 supplementation also improved overall β-cell function and fat metabolism. This means that not only did EPA and DHA reduce inflammation linked to high cholesterol, but they also appeared to enhance metabolic health.
Additionally, we found that the supplementation reduced the association between WAT inflammasome activity and various cardiometabolic risk factors, such as increased body fat. In laboratory tests, EPA and DHA inhibited WAT IL-1β secretion in a dose-dependent manner. These findings suggest that incorporating EPA and DHA into our diets may help prevent diabetes and its related health issues in individuals with high apoB levels.
Remarkably, our results showed that EPA and DHA treatment effectively normalized the IL-1β secretion levels in participants who initially had high apoB. After the intervention, LDL cholesterol no longer triggered IL-1β secretion, and the omega-3 supplementation also improved overall β-cell function and fat metabolism. This means that not only did EPA and DHA reduce inflammation linked to high cholesterol, but they also appeared to enhance metabolic health.
Additionally, we found that the supplementation reduced the association between WAT inflammasome activity and various cardiometabolic risk factors, such as increased body fat. In laboratory tests, EPA and DHA inhibited WAT IL-1β secretion in a dose-dependent manner. These findings suggest that incorporating EPA and DHA into our diets may help prevent diabetes and its related health issues in individuals with high apoB levels.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.7
9.5
Cholesterol reduction
Omega-3 acids cleanse blood vessel walls from excess high cholesterol, helping prevent cholesterol plaques. They improve blood viscosity and normalise blood pressure while increasing the level of "good" cholesterol, HDL, and strengthen blood vessel walls, enhancing their elasticity.
Read More
9.5
Effective treatment
The correct ratio of DHA to EPA (2:1) and high purification quality significantly impact high cholesterol levels.
9.5
Lower cholesterol
Omega-3 reduces harmful cholesterol levels in the blood. They serve as a building block for neural membranes and are involved in oxygen transportation.
